PI3K-IN-22

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PI3K-IN-22

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1202884-94-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PI3K-IN-22 是一种PI3Kα/mTOR双重激酶抑制剂。PI3K-IN-22 对 PI3Kα 和 mTOR 的IC₅₀s 值分别为 0.9、0.6 nM。PI3K-IN-22 可用于癌症研究。

生物活性

PI3K-IN-22 is aPI3Kα/mTORdual kinase inhibitor. PI3K-IN-22 hasIC₅₀s of 0.9, 0.6 nM forPI3KαandmTOR, respectively. PI3K-IN-22 can be used for the research ofcancer^[1].

IC₅₀& Target^[1]

PI3Kα

0.9 nM (IC₅₀)

mTOR

0.6 nM (IC₅₀)

体外研究
(In Vitro)

PI3K-IN-22 (compound 46) inhibits the cell growth of PC3 and MDA-361 cells with IC₅₀s of<3.0 and 13.0 nM^[1].

体内研究
(In Vivo)

PI3K-IN-22 (25 mg/kg; i.v.) suppresses phosphorylation of Akt T308, Akt S473 and S6K in MDA361 breast tumor cells up to 8 h in MDA361 tumor bearing nude mice demonstrated by biomarker studies^[1].
PI3K-IN-22 (50, 25, 10 mg/kg; i.v.; once daily for 5 days weekly; 2 rounds) shows good antitumor efficacy in MDA361 tumor xenograft nude mice model^[1].
PI3K-IN-22 (25 mg/kg; i.v.; a single dose) has a blood concentrationsat value of 1731 ng/mL at 8 h^[1].

Animal Model:	MDA361 tumor xenograft nude mice model^[1]
Dosage:	50, 25, 10 mg/kg
Administration:	i.v., once daily for 5 days weekly (2 rounds)
Result:	Exhibited significant tumor regression in 50 mg/kg and no tumor regrowth until day 32. Exhibited tumor growth inhibition in 25 and 10 mg/kg.

分子量

624.66

Formula

C₃₁H₃₅F₃N₈O₃

CAS 号

1202884-94-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.