PI3Kα/mTOR-IN-1

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PI3Kα/mTOR-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1013098-90-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PI3Kα/mTOR-IN-1 是一种有效的PI3Kα/mTOR双重抑制剂，在细胞实验中对PI3Kα的IC₅₀值为 7 nM，在体外酶实验中对mTOR和PI3Kα的K_i值分别为 10.6 nM 和 12.5 nM。

生物活性

PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with anIC₅₀of 7 nM forPI3Kαin a cell assay, andK_is of 10.6 nM and 12.5 nM formTORandPI3Kαin a cell free assay , respectively.

IC₅₀& Target^[1]

PI3Kα

7 nM (IC₅₀, Cell Assay)

PI3Kα

12.5 nM (Ki)

mTOR

10.6 nM (Ki)

体外研究
(In Vitro)

PI3Kα/mTOR-IN-1 exhibits potent activity against PI3Kα and mTOR, high LipE, good kinase selectivity and robust ADMET properties^[1].

体内研究
(In Vivo)

PI3Kα/mTOR-IN-1 exhibits low HLM ER, but it is highly cleared in rat liver microsome (RLM) with ER of 0.88. PI3Kα/mTOR-IN-1 exhibits moderate clearance, moderate V_dss, T_1/2of 0.9 h, and good oral bioavailability^[1].

分子量

310.35

Formula

C₁₆H₁₈N₆O

CAS 号

1013098-90-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.