Pomalidomide-amido-C1-Br is a synthesizedE3 ligase ligand-linker conjugatethat incorporates the Pomalidomide basedcereblonligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-RafPROTACdegraderPROTACB-Raf degrader 1 (HY-111758).PROTACB-Raf degrader 1 has anti-cancer activity^[1].

Pomalidomide-amido-C1-Br (Compound 6) can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (Compound 2). PROTAC B-Raf degrader 1 can effectively kill cancer cells via inducing cells apoptosis. As a B-Raf degrader, PROTAC B-Raf degrader 1 can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system, and further affects the expression of Mcl-1, a downstream protein of B-Raf^[1].

394.18

Solid

C₁₅H₁₂BrN₃O₅

2351106-38-0

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)