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OSW-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OSW-1图片
CAS NO:145075-81-6
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
OSW-1 是从 Ornithogalum caudatum 中分离出来的,是人类癌症细胞系中具有纳摩尔范围内 GI50 的甾醇结合蛋白 (OSBP) 和 OSBP 相关蛋白 4 (ORP4) 的特异性拮抗剂。
Cas No.145075-81-6
Canonical SMILESO=C(CCC(C)C)[C@@H](C)[C@@]1(O)[C@@H](O[C@@H]2OC[C@H](O)[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3OC(C4=CC=C(OC)C=C4)=O)[C@H]2OC(C)=O)C[C@@]5([H])[C@]6([H])CC=C7C[C@@H](O)CC[C@]7(C)[C@@]6([H])CC[C@@]51C
分子式C47H68O15
分子量873
溶解度Methanol: soluble
储存条件Store at -20℃, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

OSW-1 is a saponin that has been found in O. saundersiae and has antiviral and anticancer activities.1 It is an inhibitor of oxysterol-binding protein (OSBP) and its paralog OSBP-related protein 4 (ORP4) with Ki values of 16 and 71 nM, respectively, in radioligand binding assays using HEK293T cell lysates.2 It induces OSBP translocalization from the cytoplasm to the trans-Golgi network and decreases intracellular levels of OSBP in HEK293 cells.2,3 OSW-1 inhibits replication of a variety of enteroviruses (IC50s = 2.4-9.4 nM), including replication of coxsackievirus B3 (CVB3) in infected HeLa R19 cells in an OSBP-dependent manner when used at a concentration of 3 nM.4 It also inhibits replication of hepatitis C virus (HCV) but not mouse hepatitis virus (MHV), a coronavirus.5 It protects against CVA9 and echovirus 2 infection in HeLa cells when used at a concentration of 10 nM.4 OSW-1 inhibits growth of HeLa and HEK293 cells (GI50s = 0.33 and 0.22 nM, respectively).2

|3. Burgett, A.W.G., Poulsen, T.B., Wangkanont, K., et al. Natural products reveal cancer cell dependence on oxysterol-binding proteins. Nat. Chem. Biol. 7(9), 639-647 (2011).|5. Strating, J.R.P.M., van der Linden, L., Albulescu, L., et al. Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell rep. 10(4), 600-615 (2015).