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ATP依赖RNA解旋酶DDX60抗体
产品介绍 靶标： DDX60 产品别名： DDX60； DExD/H-box helicase 60； DExD/H-box helicase 60； probable ATP-dependent RNA helicase DDX60； ATP-dependent RNA helicase DDX60； DEAD (Asp-Glu-Ala-Asp) box polypeptide 60； DEAD box protein 60； DEAD-box helicase 60； ATP依赖RNA解旋酶DDX60； 背景信息： DDX60 Antibody: DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling. 宿主：Rbt |
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